Conjugate gradient methods are widely used for solving large-scale unconstrained optimization problems, because they do not need the storage of matrices. In this paper, we propose a general form of three-term conjugate gradient methods which always generate a sufficient descent direction. We give a sufficient condition for the global convergence of the proposed general method. Moreover, we present a specific three-term conjugate gradient method based on the multi-step quasi-Newton method. Finally, some numerical results of the proposed method are given.