Branch-and-Bound (B&B) is perhaps the most fundamental algorithm for the global solution of convex Mixed-Integer Nonlinear Programming (MINLP) problems. It is well-known that carrying out branching in a non-simplistic manner can greatly enhance the practicality of B&B in the context of Mixed-Integer Linear Programming (MILP). No detailed study of branching has heretofore been carried out for MINLP, In this paper, we study and identify useful sophisticated branching methods for MINLP.