In this article, we continue our work (Krug et al., 2021) on time-domain decomposition of optimal control problems for systems of semilinear hyperbolic equations in that we now consider mixed two-point boundary value problems and provide an in-depth well-posedness analysis. The more general boundary conditions significantly enlarge the scope of applications, e.g., to hyperbolic problems on metric graphs with cycles. We design an iterative method based on the optimality systems that can be interpreted as a decomposition method for the original optimal control problem into virtual control problems on smaller time domains.