Projection-free optimization via different variants of the Frank-Wolfe (FW) method has become one of the cornerstones in large scale optimization for machine learning and computational statistics. Numerous applications within these fields involve the minimization of functions with self-concordance like properties. Such generalized self-concordant (GSC) functions do not necessarily feature a Lipschitz continuous gradient, nor are they strongly convex. Indeed, in a number of applications, e.g. inverse covariance estimation or distance-weighted discrimination problems in support vector machines, the loss is given by a GSC function having unbounded curvature, implying absence of theoretical guarantees for the existing FW methods. This paper closes this apparent gap in the literature by developing provably convergent FW algorithms with standard O(1/k) convergence rate guarantees. If the problem formulation allows the efficient construction of a local linear minimization oracle, we develop a FW method with linear convergence rate.