Nikolaos Lappas

Portfolio-wide Optimization of Pharmaceutical R&D Activities Using Mathematical Programming

  • Jon Dieringer
  • Chrysanthos E. Gounaris
  • Sal Garcia-Munoz
  • Steve Guntz
  • Nikolaos Lappas
  • Shankarraman Vaidyaraman
  • Shekhar Viswanath
  • Hua Wang
    • Categories Scheduling Tags

    The R&D management in any major research pharmaceutical company is constantly faced with the need to make complicated activity scheduling and resource allocation decisions, as they carry out scientific work to develop new therapeutic products. This paper describes how we develop a decision support tool that allows practitioners to determine portfolio-wide optimal schedules in a … Read more

    Robust Optimization for Decision-making under Endogenous Uncertainty

  • Chrysanthos E. Gounaris
  • Nikolaos Lappas
    • Categories Robust Optimization Tags , ,

    This paper contemplates the use of robust optimization as a framework for addressing problems that involve endogenous uncertainty, i.e., uncertainty that is affected by the decision maker’s strategy. To that end, we extend generic polyhedral uncertainty sets typically considered in robust optimization into sets that depend on the actual decisions. We present the derivation of … Read more