The least-intensity feasible solution for aperture-based inverse planning in radiation therapy.

Aperture-based inverse planning (ABIP) for intensity modulated radiation therapy (IMRT) treatment planning starts with external radiation fields (beams) that fully conform to the target(s) and then superimposes sub-fields called segments to achieve complex shaping of 3D dose distributions. The segments' intensities are determined by solving a feasibility problem. The least-intensity feasible (LIF) solution, proposed and studied here, seeks a feasible solution closest to the origin, thus being of least intensity or least energy. We present a new iterative, primal-dual, algorithm for finding the LIF solution and explain our experimental observation that Cimmino's algorithm for feasibility actually converges to a close approximation of the LIF solution. Comparison with linear programming shows that Cimmino's algorithm has the additional advantage of generating much smoother solutions.


Annals of Operations Research, Vol. 119 (2003), pp. 183-203.