A Robust Optimization Method with Successive Linear Programming for Intensity Modulated Radiation Therapy

Intensity modulated radiation therapy (IMRT) is one of radiation therapies for cancers, and it is considered to be effective for complicated shapes of tumors, since dose distributions from each irradiation can be modulated arbitrary. Fluence map optimization (FMO), which optimizes beam intensities with given beam angles, is often formulated as an optimization problem with dose … Read more

Sparsity constrained split feasibility for dose-volume constraints in inverse planning of intensity-modulated photon or proton therapy

A split feasibility formulation for the inverse problem of intensity-modulated radiation therapy (IMRT) treatment planning with dose-volume constraints (DVCs) included in the planning algorithm is presented. It involves a new type of sparsity constraint that enables the inclusion of a percentage-violation constraint in the model problem and its handling by continuous (as opposed to integer) … Read more

A conjugate-gradient based approach for approximate solutions of quadratic programs

This paper deals with numerical behaviour and convergence properties of a recently presented column generation approach for optimization of so called step-and-shoot radiotherapy treatment plans. The approach and variants of it have been reported to be efficient in practice, finding near-optimal solutions by generating only a low number of columns. The impact of different restrictions … Read more

On linear infeasibility arising in intensity-modulated radiation therapy inverse planning

Intensity–modulated radiation therapy (IMRT) gives rise to systems of linear inequalities, representing the effects of radiation on the irradiated body. These systems are often infeasible, in which case one settles for an approximate solution, such as an {a,ß}–relaxation, meaning that no more than a percent of the inequalities are violated by no more than ß … Read more

Combining segment generation with direct step-and-shoot optimization in intensity-modulated radiation therapy

A method for generating a sequence of intensity-modulated radiation therapy step-and-shoot plans with increasing number of segments is presented. The objectives are to generate high-quality plans with few, large and regular segments, and to make the planning process more intuitive. The proposed method combines segment generation with direct step-and-shoot optimization, where leaf positions and segment … Read more

Continuous optimization of beamlet intensities for photon and proton radiotherapy

Inverse approaches and, in particular, intensity modulated radiotherapy (IMRT), in combination with the development of new technologies such as multi-leaf collimators (MLCs), have enabled new potentialities of radiotherapy for cancer treatment. The main mathematical tool needed in this connection is numerical optimization. In this article, the variety of continuous optimization approaches, which have been proposed … Read more

Inherent smoothness of intensity patterns for intensity modulated radiation therapy generated by simultaneous projection algorithms

The efficient delivery of intensity modulated radiation therapy (IMRT) depends on finding optimized beam intensity patterns that produce dose distributions, which meet given constraints for the tumor as well as any critical organs to be spared. Many optimization algorithms that are used for beamlet-based inverse planning are susceptible to large variations of neighboring intensities. Accurately … Read more

The least-intensity feasible solution for aperture-based inverse planning in radiation therapy.

Aperture-based inverse planning (ABIP) for intensity modulated radiation therapy (IMRT) treatment planning starts with external radiation fields (beams) that fully conform to the target(s) and then superimposes sub-fields called segments to achieve complex shaping of 3D dose distributions. The segments’ intensities are determined by solving a feasibility problem. The least-intensity feasible (LIF) solution, proposed and … Read more