Integer Optimization Model and Algorithm for the Stem Cell Culturing Problem

In this paper, we present a novel scheduling problem, the stem cell culturing problem (SCP), which is identified in an attempt to improve the productivity of a manufacturing system producing a commercialized autologous stem cell therapeutic product for treating an incurable disease. For a given therapeutic product along with the corresponding manufacturing process, which is … Read more

An Integer Programming Approach to the Path Selection Problems

We consider two types of path selection problems defined on arc-capacitated networks. Given an arc-capacitated network and a set of selected ordered pairs of nodes (commodity) each of which has a demand quantity, the first problem is to select a subset of commodities and setup one path for each chosen commodity to maximize profit, while … Read more