Integer Optimization Model and Algorithm for the Stem Cell Culturing Problem

In this paper, we present a novel scheduling problem, the stem cell culturing problem (SCP), which is identified in an attempt to improve the productivity of a manufacturing system producing a commercialized autologous stem cell therapeutic product for treating an incurable disease. For a given therapeutic product along with the corresponding manufacturing process, which is … Read more

Steiner tree network scheduling with opportunity cost of time

This paper points out the impact of opportunity cost of time (high discount rate or high rate of time preference, time-dependent profits, etc.) in designing real-world Steiner trees like electricity, gas, water, or telecommunications networks. We present the Steiner Tree Scheduling Problem which consists of finding a Steiner tree in an activity-on-arc graph that spans … Read more