Robust Inventory Routing with Flexible Time Window Allocation

This paper studies a robust maritime inventory routing problem with time windows and stochastic travel times. One of the novelties of the problem is that the length and placement of the time windows are also decision variables. Such problems arise in the design and negotiation of long-term delivery contracts with customers who require on-time deliveries … Read more

Minimax optimization for handling range and setup uncertainties in proton therapy

Purpose: Intensity modulated proton therapy (IMPT) is sensitive to errors, mainly due to high stopping power dependency and steep beam dose gradients. Conventional margins are often insufficient to ensure robustness of treatment plans. In this article, a method is developed that takes the uncertainties into account during the plan optimization. Methods: Dose contributions for a … Read more