Multistage Stochastic Fractionated Intensity Modulated Radiation Therapy Planning

Intensity modulated radiation therapy (IMRT) is a widely used cancer treatment technique designed to target malignant cells. To enhance its effectiveness on tumors and reduce side effects, radiotherapy plans are usually divided into consecutive treatments, or fractions, that are delivered over multiple weeks. However, typical planning approaches have focused on finding the full sequence of … Read more

On the Impact of Deep Learning-based Time-series Forecasts on Multistage Stochastic Programming Policies

Multistage stochastic programming provides a modeling framework for sequential decision-making problems that involve uncertainty. One typically overlooked aspect of this methodology is how uncertainty is incorporated into modeling. Traditionally, statistical forecasting techniques with simple forms, e.g., (first-order) autoregressive time-series models, are used to extract scenarios to be added to optimization models to represent the uncertain … Read more