radiation therapy

Adjustable robust treatment-length optimization in radiation therapy

  • Ali Ajdari
  • Thomas Bortfeld
  • Dick den Hertog
  • Stefan ten Eikelder
    • Categories Biomedical Applications, Robust Optimization Tags , ,

    Traditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation of RT course, using population-wide estimates for patients’ response to therapy. However, recent technological advancements have enabled monitoring individual patient response during the RT course, in the form of biomarkers. Although biomarker data remains subject to substantial uncertainties, information extracted from … Read more

    Iterative Solution Methods for Beam Angle and Fluence Map Optimization in Intensity Modulated Radiation Therapy Planning

  • Jaewon Choi
  • Gino J. Lim
  • Radhe Mohan
    • Categories Biomedical Applications Tags , , ,

    We present computational approaches for optimizing beam angles and fluence maps in Intensity Modulated Radiation Therapy (IMRT) planning. We assume that the number of angles to be used for the treatment is given by the treatment planner. A mixed integer programming (MIP) model and a linear programming (LP) model are used to find an optimal … Read more

    Mathematical optimization for the inverse problem of intensity modulated radiation therapy

  • Yair Censor
    • Categories Biomedical Applications, Global Optimization Applications Tags , , , , ,

    In this tutorial we discuss modeling issues in intensity modulated radiation therapy, contrasting the continuous model with the fully-discretized one and considering feasibility formulations versus optimization setups. We review briefly some mathematical optimization techniques for IMRT. These include global optimization, multi-objective optimization, linear and mixed integer programming and projection methods. Citation in: J.R. Palta and … Read more