differential equations

Combination Chemotherapy Optimization

  • Temitayo Ajayi
  • Seyedmohammadhossein Hosseinian
  • Andrew J. Schaefer
  • Clifton D. Fuller
    • Categories (Mixed) Integer Linear Programming, Biomedical Applications Tags , ,

    Chemotherapy is one of the primary modalities of cancer treatment. Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens. One way to alleviate this burden and better inform future trials is to build reliable models for drug administration. Previous chemotherapy optimization models have mainly relied on optimal … Read more

    On the Difficulty of Deciding Asymptotic Stability of Cubic Homogeneous Vector Fields

  • Amir Ali Ahmadi
    • Categories Control Applications, Semi-definite Programming, Systems governed by Differential Equations Optimization Tags , ,

    It is well-known that asymptotic stability (AS) of homogeneous polynomial vector fields of degree one (i.e., linear systems) can be decided in polynomial time e.g. by searching for a quadratic Lyapunov function. Since homogeneous vector fields of even degree can never be AS, the next interesting degree to consider is equal to three. In this … Read more