model calibration

A homotopy for the reliable estimation of model parameters in chromatography processes

  • Dominik H. Cebulla
  • Christian Kirches
  • Andreas Potschka
    • Categories Chemical Engineering, Nonlinear Systems and Least-Squares, Optimization of Systems modeled by PDEs Tags , , ,

    Mathematical modeling, simulation, and optimization can significantly support the development and characterization of chromatography steps in the biopharmaceutical industry. Particularly mechanistic models become preferably used, as these models, once carefully calibrated, can be employed for a reliable optimization. However, model calibration is a difficult task in this context due to high correlations between parameters, highly … Read more

    A simulation-based optimization approach for the calibration of a discrete event simulation model of an emergency department

  • Alberto De Santis
  • Tommaso Giovannelli
  • Stefano Lucidi
  • Mauro Messedaglia
  • Massimo Roma
    • Categories Applications - OR and Management Sciences, Integer Programming, Optimization of Simulated Systems Tags , , , ,

    Accurate modeling of the patient flow within an Emergency Department (ED) is required by all studies dealing with the increasing and well-known problem of overcrowding. Since Discrete Event Simulation (DES) models are often adopted with the aim of assessing solutions for reducing the impact of this worldwide phenomenon, an accurate estimation of the service time … Read more