Dominik H. Cebulla

A homotopy for the reliable estimation of model parameters in chromatography processes

  • Dominik H. Cebulla
  • Christian Kirches
  • Andreas Potschka
    • Categories Chemical Engineering, Nonlinear Systems and Least-Squares, Optimization of Systems modeled by PDEs Tags , , ,

    Mathematical modeling, simulation, and optimization can significantly support the development and characterization of chromatography steps in the biopharmaceutical industry. Particularly mechanistic models become preferably used, as these models, once carefully calibrated, can be employed for a reliable optimization. However, model calibration is a difficult task in this context due to high correlations between parameters, highly … Read more

    Mixed-Integer Optimal Control for Multimodal Chromatography

  • Hans Georg Bock
  • Christian Kirches
  • Andreas Potschka
  • Dominik H. Cebulla
    • Categories (Mixed) Integer Nonlinear Programming, Chemical Engineering, Systems governed by Differential Equations Optimization Tags , , ,

    Multimodal chromatography is a powerful tool in the downstream processing of biopharmaceuticals. To fully benefit from this technology, an efficient process strategy must be determined beforehand. To facilitate this task, we employ a recent mechanistic model for multimodal chromatography, which takes salt concentration and pH into account, and we present a mathematical framework for the … Read more