perishable products

A multi-period production and distribution optimization model for radiopharmaceuticals

  • Ioannis G. Akrotirianakis
  • Amit Chakraborty
    • Categories (Mixed) Integer Nonlinear Programming, Biomedical Applications, Production and Logistics Tags , , ,

    This paper addresses the manufacturing and distribution of short-lived radio-pharmaceuticals which are mainly used in diagnostic imaging studies. We develop a mixed integer nonlinear optimization model that is flexible enough to capture the complex underlying nuclear physics of the production process of fludeoxyglucose (FDG), which is widely used in oncology and cardiology, as well as … Read more

    An optimization-based approach for delivering radio-pharmaceuticals to medical imaging centers

  • Ioannis G. Akrotirianakis
  • Amit Chakraborty
    • Categories Applications - OR and Management Sciences, Integer Programming, Network Optimization Tags , , , ,

    It is widely recognized that early diagnosis of most types of cancers can increase the chances of full recovery or substantially prolong the life of patients. Positron Emission Tomography (PET) has become the standard way to diagnose many types of cancers by generating high quality images of the affected organs. In order to create an … Read more