Hans Georg Bock Multimodal chromatography is a powerful tool in the downstream processing of biopharmaceuticals. To fully benefit from this technology, an efficient process strategy must be determined beforehand. To facilitate this task, we employ a recent mechanistic model for multimodal chromatography, which takes salt concentration and pH into account, and we present a mathematical framework for the … Read more
In this article, we present a unified framework for the numerical solution of optimal control problems constrained by ordinary differential equations with both implicit and explicit switches. We present the problem class and qualify different types of implicitly switched systems. This classification significantly affects opportunities for solving such problems numerically. By using techniques from generalized … Read more
This paper considers a bilevel nonlinear program (NLP) whose lower-level problem satisfies a linear independence constraint qualification (LICQ) and a strong second-order condition (SSOC). One would expect the resulting mathematical program with complementarity constraints (MPCC), whose constraints are the first-order optimality conditions of the lower-level NLP, to satisfy an MPEC-LICQ. We provide an example which … Read more
We address direct multiple shooting based algorithms for nonlinear model predictive control, with a focus on problems with long prediction horizons. We describe different efficient multiple shooting variants with a computational effort that is only linear in the horizon length. Proposed techniques comprise structure exploiting linear algebra on the one hand, and approximation of derivative … Read more
Combinatorial and logic constraints arising in a number of challenging optimization applications can be formulated as vanishing constraints. Quadratic programs with vanishing constraints (QPVCs) then arise as subproblems during the numerical solution of such problems using algorithms of the Sequential Quadratic Programming type. QPVCs are nonconvex problems violating standard constraint qualifications. In this paper, we … Read more
Parametric Active Set Methods (PASM) are a relatively new class of methods to solve convex Quadratic Programming (QP) problems. They are based on tracing the solution along a linear homotopy between a QP with known solution and the QP to be solved. We explicitly identify numerical challenges in PASM and develop strategies to meet these … Read more
We develop and investigate two preconditioners for a basic linear iterative splitting method for the numerical solution of linear-quadratic optimization problems with time-periodic parabolic PDE constraints. The resulting real-valued linear system to be solved is symmetric indefinite. We propose all-at-once symmetric indefinite preconditioners based on a Newton–Picard approach which divides the variable space into slow … Read more
Quadratic programs obtained for optimal control problems of dynamic or discrete–time processes usually involve highly block structured Hessian and constraints matrices. Efficient numerical methods for the solution of such QPs have to respect and exploit this block structure. In interior point methods, this is elegantly achieved by the widespread availability of advanced sparse symmetric indefinite … Read more
In this contribution we address the efficient solution of optimal control problems of dynamic processes with many controls. Such problems arise, e.g., from the outer convexification of integer control decisions. We treat this optimal control problem class using the direct multiple shooting method to discretize the optimal control problem. The resulting nonlinear problems are solved … Read more
We extend recent work on nonlinear optimal control problems with integer restrictions on some of the control functions (mixed-integer optimal control problems, MIOCP) in two ways. We improve a theorem that states that the solution of a relaxed and convexified problem can be approximated with arbitrary precision by a solution fulfilling the integer requirements. Unlike … Read more