Flavio Yano

Continuous Optimization Methods for Structure Alignments

  • Roberto Andreani
  • Leandro Martínez
  • José Mario Martínez
  • Flavio Yano
    • Categories Basic Sciences Applications, Nonlinear Optimization Tags , , , ,

    Structural Alignment is an important tool for fold identification of proteins, structural screening on ligand databases, pharmacophore identification and other applications. In the general case, the optimization problem of superimposing two structures is nonsmooth and nonconvex, so that most popular methods are heuristic and do not employ derivative information. Usually, these methods do not admit … Read more

    Low Order-Value Optimization and Applications

  • Roberto Andreani
  • Leandro Martínez
  • José Mario Martínez
  • Flavio Yano
    • Categories Applications - OR and Management Sciences, Applications - Science and Engineering, Nonlinear Optimization Tags , , ,

    Given r real functions F1 (x), . . . , Fr (x) and an integer p between 1 and r, the Low Order- Value Optimization problem (LOVO) consists of minimizing the sum of the functions that take the p smaller values. If (y1 , . . . , yr ) is a vector of data … Read more