We study a class of quadratic stochastic programs where the distribution of random variables has unknown parameters. A traditional approach is to estimate the parameters using a maximum likelihood estimator (MLE) and to use this as input in the optimization problem. For the unconstrained case, we show that an estimator that “shrinks” the MLE towards … Read more
Metabolic networks are defined as the collection of biochemical reactions within a cell that define the functions of that cell. Due to the growing need to understand the functions of biological organisms for industrial and medical purposes, modeling and simulation of metabolic networks has attracted a lot of attention recently. Traditionally, metabolic networks are modeled … Read more
The objectives of this paper are twofold; we first demonstrate the flexibility of the mesh adaptive direct search (MADS) in identifying locally optimal algorithmic parameters. This is done by devising a general framework for parameter tuning. The framework makes provision for surrogate objectives. Parameters are sought so as to minimize some measure of performance of … Read more