A method for finding all roots of a system of nonlinear equations is described. Our method makes use of C-GRASP, a recently proposed continuous global optimization heuristic. Given a nonlinear system, we solve a corresponding adaptively modified global optimization problem multiple times, each time using C-GRASP, with areas of repulsion around roots that have already … Read more
Adverse drug reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reactions that they cause. We formulate the drug-reaction relationship problem as a continuous optimization problem and … Read more
Continuous GRASP (C-GRASP) is a stochastic local search metaheuristic for finding cost-efficient solutions to continuous global optimization problems subject to box constraints (Hirsch et al., 2006). Like a greedy randomized adaptive search procedure (GRASP), a C-GRASP is a multi-start procedure where a starting solution for local improvement is constructed in a greedy randomized fashion. In … Read more
In this paper we consider global optimization algorithms based on multiple local searches for the Molecular Distance Geometry Problem (MDGP). Three distinct approaches (Multistart, Monotonic Basin Hopping, Population Basin Hopping) are presented and for each of them a computational analysis is performed. The results are also compared with those of two other approaches in the … Read more
We introduce a novel global optimization method called Continuous GRASP (C-GRASP) which extends Feo and Resende’s greedy randomized adaptive search procedure (GRASP) from the domain of discrete optimization to that of continuous global optimization. This stochastic local search method is simple to implement, is widely applicable, and does not make use of derivative information, thus … Read more
Wasps, bees, ants and termites all make effective use of their environment and resources by displaying collective “swarm” intelligence. Termite colonies – for instance – build nests with a complexity far beyond the comprehension of the individual termite, while ant colonies dynamically allocate labor to various vital tasks such as foraging or defense without any … Read more
In order to overcome difficult dynamic optimization and environment extrema tracking problems, we propose a Self-Regulated Swarm (SRS) algorithm which hybridizes the advantageous characteristics of Swarm Intelligence as the emergence of a societal environmental memory or cognitive map via collective pheromone laying in the landscape (properly balancing the exploration/exploitation nature of the search strategy), with … Read more
We present a new computational approach to the problem of placing $n$ identical non overlapping disks in the unit square in such a way that their radius is maximized. The problem has been studied in a large number of papers, both from a theoretical and from a computational point of view. In this paper we … Read more
We propose a Greedy Randomized Adaptive Search Procedure (GRASP) for solving continuous global optimization problems subject to box constraints. The method was tested on benchmark functions and the computational results show that our approach was able to find, in a few seconds, optimal solutions for all tested functions despite not using any gradient information about … Read more
The problem of finding the optimal placement of $N$ identical, non overlapping, circles with maximum radius in the unit square is a well known challenge both in classical geometry and in optimization. A database of putative optima is currently maintained at \url{www.packomania.com}. Recently, through clever use of an extremely simple global optimization method, we succeeded … Read more