Global Optimization Applications

Mathematical optimization for the inverse problem of intensity modulated radiation therapy

  • Yair Censor
    • Categories Biomedical Applications, Global Optimization Applications Tags , , , , ,

    In this tutorial we discuss modeling issues in intensity modulated radiation therapy, contrasting the continuous model with the fully-discretized one and considering feasibility formulations versus optimization setups. We review briefly some mathematical optimization techniques for IMRT. These include global optimization, multi-objective optimization, linear and mixed integer programming and projection methods. Citationin: J.R. Palta and T.R. … Read more

    A randomized global optimization method for protein-protein docking

  • Bernardetta Addis
  • Fabio Schoen
    • Categories Biomedical Applications, Global Optimization Applications, Stochastic Approaches Tags , ,

    In this paper we report results on the problem of docking two large proteins by means of a two-phase monotonic basin hopping method. Given an appropriate force field which is used to measure the interaction energy between two biomolecules which are considered as rigid bodies, we used a randomized global optimization methods based upon the … Read more

    A fast swap-based local search procedure for location problems

  • Mauricio G.C. Resende
  • Renato F. Werneck
    • Categories Applications - OR and Management Sciences, Combinatorial Optimization, Global Optimization Applications Tags , ,

    We present a new implementation of a widely used swap-based local search procedure for the P-median problem, proposed in 1968 by Teitz and Bart. Our method produces the same output as the best alternatives described in the literature and, even though its worst-case complexity is similar, it can be significantly faster in practice: speedups of … Read more

    Global Optimization: Software, Test Problems, and Applications

  • János Pintér
    • Categories Global Optimization, Global Optimization Applications, Optimization Software and Modeling Systems Tags , , , ,

    We provide a concise review of the most prominent global optimization (GO) strategies currently available. This is followed by a discussion of GO software, test problems and several important types of applications, with additional pointers. The exposition is concentrated around topics related to continuous GO, although in certain aspects it is also pertinent to analogous … Read more

    A New Second-Order Cone Programming Relaxation for MAX-CUT problems

  • Masakazu Muramatsu
  • Tsunehiro Suzuki
    • Categories Combinatorial Optimization, Global Optimization Applications, Linear, Cone and Semidefinite Programming Tags , , , ,

    We propose a new relaxation scheme for the MAX-CUT problem using second-order cone programming. We construct relaxation problems to reflect the structure of the original graph. Numerical experiments show that our relaxation approaches give better bounds than those based on the spectral decomposition proposed by Kim and Kojima, and that the efficiency of the branch-and-bound … Read more