Bi-level multi-criteria optimization to include linear energy transfer into proton treatment planning

In proton therapy treatment planning, the aim is to ensure tumor control while sparing the various surrounding risk structures. The biological effect of the irradiation depends on both physical dose and linear energy transfer (LET). In order to include LET alongside physical dose in plan creation, we propose to formulate the proton treatment planning problem … Read more

Integer Programming Formulations for Minimum Spanning Tree Interdiction

We consider a two-player interdiction problem staged over a graph where the leader’s objective is to minimize the cost of removing edges from the graph so that the follower’s objective, i.e., the weight of a minimum spanning tree in the residual graph, is increased up to a predefined level $r$. Standard approaches for graph interdiction … Read more

On the convergence of stochastic bi-level gradient methods

We analyze the convergence of stochastic gradient methods for bi-level optimization problems. We address two specific cases: first when the outer objective function can be expressed as a finite sum of independent terms, and next when both the outer and inner objective functions can be expressed as finite sums of independent terms. We assume Lipschitz … Read more