Superiorization as a novel strategy for linearly constrained inverse radiotherapy treatment planning

Objective: We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a feasibility-seeking projection algorithm will seek a feasible point. This algorithm is then perturbed with gradient descent steps to reduce a nonlinear objective function. Approach: Within … Read more

An analysis of the superiorization method via the principle of concentration of measure

The superiorization methodology is intended to work with input data of constrained minimization problems, i.e., a target function and a constraints set. However, it is based on an antipodal way of thinking to the thinking that leads constrained minimization methods. Instead of adapting unconstrained minimization algorithms to handling constraints, it adapts feasibility-seeking algorithms to reduce … Read more