radiation therapy treatment planning

Superiorization as a novel strategy for linearly constrained inverse radiotherapy treatment planning

  • Florian Barkmann
  • Yair Censor
  • Niklas Wahl
    • Categories Biomedical Applications, Constrained Nonlinear Optimization, Convex Optimization Tags , , , , , ,

    Objective: We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a feasibility-seeking projection algorithm will seek a feasible point. This algorithm is then perturbed with gradient descent steps to reduce a nonlinear objective function. Approach: Within … Read more

    Dynamic string-averaging CQ-methods for the split feasibility problem with percentage violation constraints arising in radiation therapy treatment planning

  • Mark Brooke
  • Yair Censor
  • Aviv Gibali
    • Categories Biomedical Applications, Nonlinear Optimization Tags , , , , , , ,

    We study a feasibility-seeking problem with percentage violation constraints. These are additional constraints, that are appended to an existing family of constraints, which single out certain subsets of the existing constraints and declare that up to a specified fraction of the number of constraints in each subset is allowed to be violated by up to … Read more

    Dynamic string-averaging CQ-methods for the split feasibility problem with percentage violation constraints arising in radiation therapy treatment planning

  • Mark Brooke
  • Yair Censor
  • Aviv Gibali
    • Categories Biomedical Applications, Constrained Nonlinear Optimization, Convex Optimization Tags , , , , , , , , ,

    In this paper we study a feasibility-seeking problem with percentage violation con- straints. These are additional constraints, that are appended to an existing family of constraints, which single out certain subsets of the existing constraints and declare that up to a speci ed fraction of the number of constraints in each subset is allowed to be … Read more

    Objective Selection for Cancer Treatment: An Inverse Optimization Approach

  • Temitayo Ajayi
  • Andrew J. Schaefer
  • Taewoo Lee
    • Categories Biomedical Applications, Convex and Nonsmooth Optimization, Multi-Criteria Optimization Tags , , , , , ,

    In radiation therapy treatment-plan optimization, selecting a set of clinical objectives that are tractable and parsimonious yet effective is a challenging task. In clinical practice, this is typically done by trial and error based on the treatment planner’s subjective assessment, which often makes the planning process inefficient and inconsistent. We develop the objective selection problem … Read more