This paper presents a new two-phase solution approach to the beam angle and fluence map optimization problem in Intensity Modulated Radiation Therapy (IMRT) planning. We introduce Branch-and-Prune (B&P) to generate a robust feasible solution in the first phase. A local neighborhood search algorithm is developed to find a local optimal solution from the Phase I … Read more
Radiation therapy is an important modality in treating various cancers. Various treatment planning and delivery technologies have emerged to support Intensity Modulated Radiation Therapy (IMRT), creating significant opportunities to advance this type of treatment. We investigate the possibility of including the dose prescription, specified by the DVH, within the convex optimization framework for inverse IMRT … Read more
Intensity–modulated radiation therapy (IMRT) gives rise to systems of linear inequalities, representing the effects of radiation on the irradiated body. These systems are often infeasible, in which case one settles for an approximate solution, such as an {a,ß}–relaxation, meaning that no more than a percent of the inequalities are violated by no more than ß … Read more
We present computational approaches for optimizing beam angles and fluence maps in Intensity Modulated Radiation Therapy (IMRT) planning. We assume that the number of angles to be used for the treatment is given by the treatment planner. A mixed integer programming (MIP) model and a linear programming (LP) model are used to find an optimal … Read more
Inverse approaches and, in particular, intensity modulated radiotherapy (IMRT), in combination with the development of new technologies such as multi-leaf collimators (MLCs), have enabled new potentialities of radiotherapy for cancer treatment. The main mathematical tool needed in this connection is numerical optimization. In this article, the variety of continuous optimization approaches, which have been proposed … Read more