Developments in mathematical algorithms and computational tools for proton CT and particle therapy treatment planning

We summarize recent results and ongoing activities in mathematical algorithms and computer science methods related to proton computed tomography (pCT) and intensitymodulated particle therapy (IMPT) treatment planning. Proton therapy necessitates a high level of delivery accuracy to exploit the selective targeting imparted by the Bragg peak. For this purpose, pCT utilizes the proton beam itself … Read more

Techniques in Iterative Proton CT Image Reconstruction

This is a review paper on some of the physics, modeling, and iterative algorithms in proton computed tomography (pCT) image reconstruction. The primary challenge in pCT image reconstruction lies in the degraded spatial resolution resulting from multiple Coulomb scattering within the imaged object. Analytical models such as the most likely path (MLP) have been proposed … Read more

Total variation superiorization schemes in proton computed tomography image reconstruction

Purpose: Iterative projection reconstruction algorithms are currently the preferred reconstruction method in proton computed tomography (pCT). However, due to inconsistencies in the measured data arising from proton energy straggling and multiple Coulomb scattering, noise in the reconstructed image increases with successive iterations. In the current work, we investigated the use of total variation superiorization (TVS) … Read more

Block-Iterative and String-Averaging Projection Algorithms in Proton Computed Tomography Image Reconstruction

Proton computed tomography (pCT) is an imaging modality that has been suggested as a means for reducing the range uncertainty during proton radiation treatments. By measuring the spatial location of individual protons pre- and post-patient, as well as the energy lost along the proton path, three dimensional maps of patient water equivalent electron densities can … Read more