Robust Vehicle Routing under Uncertainty via Branch-Price-and-Cut

This paper contemplates how branch-price-and-cut solvers can be employed along with the robust optimization paradigm to address parametric uncertainty in the context of vehicle routing problems. In this setting, given postulated uncertainty sets for customer demands and vehicle travel times, one aims to identify a set of cost-effective routes for vehicles to traverse, such that … Read more

Portfolio-wide Optimization of Pharmaceutical R&D Activities Using Mathematical Programming

The R&D management in any major research pharmaceutical company is constantly faced with the need to make complicated activity scheduling and resource allocation decisions, as they carry out scientific work to develop new therapeutic products. This paper describes how we develop a decision support tool that allows practitioners to determine portfolio-wide optimal schedules in a … Read more

Estimation of Marginal Cost to Serve Individual Customers

This paper proposes a scenario-sampling framework to estimate the expected incremental routing cost required so as to incorporate a target customer into the stochastic supply chain network. The cost estimate is shown to converge to its true value with statistical guarantee as the number of samples increases, while the Hoeffding’s inequality can be utilized to … Read more

On tackling reverse convex constraints for non-overlapping of unequal circles

We study the unequal circle-circle non-overlapping constraints, a form of reverse convex constraints that often arise in optimization models for cutting and packing applications. The feasible region induced by the intersection of circle-circle non-overlapping constraints is highly non-convex, and standard approaches to construct convex relaxations for spatial branch-and-bound global optimization of such models typically yield … Read more

Robust Optimization of a Broad Class of Heterogeneous Vehicle Routing Problems under Demand Uncertainty

This paper studies robust variants of an extended model of the classical Heterogeneous Vehicle Routing Problem (HVRP), where a mixed fleet of vehicles with different capacities, availabilities, fixed costs and routing costs is used to serve customers with uncertain demand. This model includes, as special cases, all variants of the HVRP studied in the literature … Read more

A scenario decomposition algorithm for strategic time window assignment vehicle routing problems

We study the strategic decision-making problem of assigning time windows to customers in the context of vehicle routing applications that are affected by operational uncertainty. This problem, known as the Time Window Assignment Vehicle Routing Problem, can be viewed as a two-stage stochastic optimization problem, where time window assignments constitute first-stage decisions, vehicle routes adhering … Read more

Robust Optimization for Decision-making under Endogenous Uncertainty

This paper contemplates the use of robust optimization as a framework for addressing problems that involve endogenous uncertainty, i.e., uncertainty that is affected by the decision maker’s strategy. To that end, we extend generic polyhedral uncertainty sets typically considered in robust optimization into sets that depend on the actual decisions. We present the derivation of … Read more

K-Adaptability in Two-Stage Mixed-Integer Robust Optimization

We study two-stage robust optimization problems with mixed discrete-continuous decisions in both stages. Despite their broad range of applications, these problems pose two fundamental challenges: (i) they constitute infinite-dimensional problems that require a finite-dimensional approximation, and (ii) the presence of discrete recourse decisions typically prohibits duality-based solution schemes. We address the first challenge by studying … Read more

Robust Multi-Period Vehicle Routing under Customer Order Uncertainty

In this paper, we study multi-period vehicle routing problems where the aim is to determine a minimum cost visit schedule and associated routing plan for each period using capacity-constrained vehicles. In our setting, we allow for customer service requests that are received dynamically over the planning horizon. In order to guarantee the generation of routing … Read more