Hans D Mittelmann We propose a novel, ecient approach for obtaining high-quality experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). Our approach combines a greedy hillclimbing algorithm and a cyclic permutation method. When searching for optimal ER-fMRI designs, the proposed approach focuses only on a promising restricted class of designs with equal frequency of occurrence across stimulus … Read more
We describe the search for explicit general linear methods in Nordsieck form for which the stability function has only two nonzero roots. This search is based on state-of-the-art optimization software. Examples of methods found in this way are given for order p = 5, p = 6, and p = 7. Article Download View Optimization-based … Read more
Channel-optimized index assignment of source codewords is arguably the simplest way of improving transmission error resilience, while keeping the source and/or channel codes intact. But optimal design of index assignment is an in- stance of quadratic assignment problem (QAP), one of the hardest optimization problems in the NP-complete class. In this paper we make a … Read more
Background: The binding of peptide fragments of antigens to class II MHC is a crucial step in initiating a helper T cell immune response. The identification of such peptide epitopes has potential applications in vaccine design and in better understanding autoimmune diseases and allergies. However, comprehensive experimental determination of peptide-MHC binding affinities is infeasible due … Read more
This work gives an overview over the major codes available for the solution of linear semidefinite (SDP) and second-order cone (SOCP) programs. Some developments since the 7th DIMACS Challenge [9, 17] are pointed out as well as some currently under way. Instead of presenting per- formance tables, reference is made to the ongoing benchmark [19] … Read more
Let A(n, d) be the maximum number of 0, 1 words of length n, any two having Hamming distance at least d. We prove A(20, 8) = 256, which implies that the quadruply shortened Golay code is optimal. Moreover, we show A(18, 6) ≤ 673, A(19, 6) ≤ 1237, A(20, 6) ≤ 2279, A(23, 6) … Read more
Channel-optimized index assignment of source codewords is arguably the simplest way of improving transmission error resilience, while keeping the source and/or channel codes intact. But optimal design of index assignment is an in- stance of quadratic assignment problem (QAP), one of the hardest optimization problems in the NP-complete class. In this paper we make a … Read more
The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a distinct subset of peptides and the enormous number of possible peptide epitopes prevents their complete experimental characterization. Computational methods can utilize the limited experimental data to predict the … Read more
The kissing number in n-dimensional Euclidean space is the maximal number of non-overlapping unit spheres which simultaneously can touch a central unit sphere. Bachoc and Vallentin developed a method to find upper bounds for the kissing number based on semidefinite programming. This paper is a report on high accuracy calculations of these upper bounds for … Read more
The kissing number in n-dimensional Euclidean space is the maximal number of non-overlapping unit spheres which simultaneously can touch a central unit sphere. Bachoc and Vallentin developed a method to find upper bounds for the kissing number based on semidefinite programming. This paper is a report on high accuracy calculations of these upper bounds for … Read more