The R&D management in any major research pharmaceutical company is constantly faced with the need to make complicated activity scheduling and resource allocation decisions, as they carry out scientific work to develop new therapeutic products. This paper describes how we develop a decision support tool that allows practitioners to determine portfolio-wide optimal schedules in a … Read more
While many heuristics have been proposed for the problem of patient-to-room assignment (PRA) with a large variety of different practical constraints, a thorough investigation of the problem’s structure itself has been neglected so far. Therefore, in this paper, we present insights about the basic, underlying combinatorial problem of PRA. At first we consider the problem … Read more
L1 spline fits are a class of spline models that have shown advantages in approximating irregular and multiscale data. This paper investigates the knot placement problem of L1 spline fits under two scenarios. If the number of knots is given, we propose an augmented Lagrangian method to solve the bilevel L1 spline fit problem and … Read more
In this paper, we study the decision process of assigning elective surgery patients to available surgical blocks in multiple operating rooms (OR) under random surgery durations, random postoperative length-of-stay in the intensive care unit (ICU), and limited capacity of ICU. The probability distributions of random parameters are assumed to be ambiguous, and only the mean … Read more
We introduce the (directed) multi-stop station location problem. The goal is to install stations such that ordered (multi-)sets of stops can be traversed with respect to range restrictions that are reset whenever a station is visited. Applications arise in telecommunications and transportation, e.g., charging station placement problems. The problem generalizes several network optimization problems such … Read more
A new multivariate performance measure Average-Value-at-Risk, mAVaR αevaluating the sum of N risky assets composing the portfolio of an investor with respect to riskN-dimensional risk level vectorαis proposed. We show that the proposed operator satisfies the four axioms of a coherent risk measure, while reducing to the one variableAverage-Value-at-RiskAVaR, in caseN= 1. In that respect, … Read more
In this paper, we study the problem of planning the growth of crops on shelves in vertical farming cabinets under controlled growth conditions. By adjusting temperature, humidity, light, and other environmental conditions in different parts of the cabinets, a planner must ensure that crop growth is able to satisfy some deterministic demand. We prove this … Read more
This work concerns the assortment optimization problem that refers to selecting a subset of items that maximizes the expected revenue in the presence of the substitution behavior of consumers specified by a parametric choice model. The key challenge lies in the computational difficulty of finding the best subset solution, which often requires exhaustive search. The … Read more
The thermal unit commitment (UC) problem often can be formulated as a mixed integer quadratic programming (MIQP), which is difficult to solve efficiently, especially for large-scale instances. The tighter characteristic re-duces the search space, therefore, as a natural conse-quence, significantly reduces the computational burden. In the literature, many tightened formulations for single units with parts … Read more
Mine planning optimization aims at maximizing the profit obtained from extracting valuable ore. Beyond its theoretical complexity (the open-pit mining problem with capacity constraints reduces to a knapsack problem with precedence constraints, which is NP-hard), practical instances of the problem usually involve a large to very large number of decision variables, typically of the order … Read more