Mixed-Integer Programming for Cycle Detection in Non-reversible Markov Processes

In this paper, we present a new, optimization-based method to exhibit cyclic behavior in non-reversible stochastic processes. While our method is general, it is strongly motivated by discrete simulations of ordinary differential equations representing non-reversible biological processes, in particular molecular simulations. Here, the discrete time steps of the simulation are often very small compared to … Read more

SCIP: Global Optimization of Mixed-Integer Nonlinear Programs in a Branch-and-Cut Framework

This paper describes the extensions that were added to the constraint integer programming framework SCIP in order to enable it to solve convex and nonconvex mixed-integer nonlinear programs (MINLPs) to global optimality. SCIP implements a spatial branch-and-bound algorithm based on a linear outer-approximation, which is computed by convex over- and underestimation of nonconvex functions. An … Read more

Towards an accurate solution of wireless network design problems

The optimal design of wireless networks has been widely studied in the literature and many optimization models have been proposed over the years. However, most models directly include the signal-to-interference ratios representing service coverage conditions. This leads to mixed-integer linear programs with constraint matrices containing tiny coefficients that vary widely in their order of magnitude. … Read more

The SCIP Optimization Suite 3.2

The SCIP Optimization Suite is a software toolbox for generating and solving various classes of mathematical optimization problems. Its major components are the modeling language ZIMPL, the linear programming solver SoPlex, the constraint integer programming framework and mixed-integer linear and nonlinear programming solver SCIP, the UG framework for parallelization of branch-and-bound-based solvers, and the generic … Read more

Three Enhancements for Optimization-Based Bound Tightening

Optimization-based bound tightening (OBBT) is one of the most effective procedures to reduce variable domains of nonconvex mixed-integer nonlinear programs (MINLPs). At the same time it is one of the most expensive bound tightening procedures, since it solves auxiliary linear programs (LPs)—up to twice the number of variables many. The main goal of this paper … Read more

Iterative Refinement for Linear Programming

We describe an iterative refinement procedure for computing extended precision or exact solutions to linear programming problems (LPs). Arbitrarily precise solutions can be computed by solving a sequence of closely related LPs with limited precision arithmetic. The LPs solved share the same constraint matrix as the original problem instance and are transformed only by modification … Read more