We develop Quasi-Newton methods for distributed parameter estimation problems, where the forward problem is governed by a set of partial differential equations. A Tikhonov style regularization approach yields an optimization problem with a special structure, where the gradients are calculated using the adjoint method. In many cases standard Quasi-Newton methods (such as L-BFGS) are not … Read more
In this paper we report results on the problem of docking two large proteins by means of a two-phase monotonic basin hopping method. Given an appropriate force field which is used to measure the interaction energy between two biomolecules which are considered as rigid bodies, we used a randomized global optimization methods based upon the … Read more
We consider primal-dual algorithms for certain types of infinite-dimensional optimization problems. Our approach is based on the generalization of the technique of finite-dimensional Euclidean Jordan algebras to the case of infinite-dimensional JB-algebras of finite rank. This generalization enables us to develop polynomial-time primal-dual algorithms for “infinite-dimensional second-order cone programs.” We consider as an example a … Read more
We present a new formulation of the truss topology problem that results in unique design and unique displacements of the optimal truss. This is reached by adding an upper level to the original optimization problem and formulating the new problem as an MPCC (Mathematical Program with Complementarity Constraints). We derive optimality conditions for this problem … Read more
We recently discovered 5 new putative globally optimum configurations for Morse clusters at $\rho=8$. This report contains some algorithmic details as well as the structures determined with our method. Citation Technical Report DSI 3-2003, Dipartimento di Sistemi e Informatica, Università degli Studi di Firenze, Firenze, 2003. Article Download View New global optima for Morse clusters … Read more
A single facility has to be located in competition with fixed existing facilities of similar type. Demand is supposed to be concentrated at a finite number of points, and consumers patronise the facility to which they are attracted most. Attraction is expressed by some function of the quality of the facility and its distance to … Read more
The effectiveness of a layout design cannot be completely measured if the operational characteristics of the manufacturing system are ignored. There is, therefore, a need to develop integrated manufacturing system design models. In this paper, the integration of unit load and material handling considerations in facility layout design is presented. This integration is based on … Read more
The distance-based facility layout problem with unequal-area departments has been studied by many researchers for over 30 years. Still, current approaches require certain assumptions that limit the type of solutions obtained. In this paper, we consider manufacturing systems in which replicates of the same machine type may exist in the facility and propose an extended … Read more
This paper develops a new mathematical model that integrates layout design and production planning to prescribe efficient multi-bay manufacturing facilities. The model addresses the need to distribute department replicas throughout the facility and extends the use of product and process requirements as problem parameters in order to increase process routing flexibility. In addition, the model … Read more
We present two capacity choice scenarios for the socially optimal location of facilities with fixed servers, stochastic demand and congestion. Walk-in health clinics, motor vehicle inspection stations, automobile emissions testing stations, and internal service systems are motivating examples of such facilities. The choice of locations for such facilities influences not only distances for users traveling … Read more