This paper addresses the manufacturing and distribution of short-lived radio-pharmaceuticals which are mainly used in diagnostic imaging studies. We develop a mixed integer nonlinear optimization model that is flexible enough to capture the complex underlying nuclear physics of the production process of fludeoxyglucose (FDG), which is widely used in oncology and cardiology, as well as … Read more
Perspective functions have long been used to convert fractional programs into convex programs. More recently, they have been used to form tight relaxations of mixed-integer nonlinear programs with so-called indicator variables. Motivated by a practical application (maximising energy efficiency in an OFDMA system), we consider problems that have a fractional objective and indicator variables simultaneously. … Read more
The solver DICOPT is based on an outer-approximation algorithm used for solving mixed- integer nonlinear programming (MINLP) problems. This algorithm is very effective for solving some types of convex MINLPs. However, there are certain problems that are dicult to solve with this algorithm. One of these problems is when the nonlinear constraints are so restrictive … Read more
In this paper, we introduce the Glider Routing and Trajectory Optimisation Problem (GRTOP), the problem of finding simultaneously optimal routes and trajectories for a fleet of gliders with the aim of surveying a set of locations. We propose a novel Mixed-Integer Nonlinear Programming (MINLP) formulation for the GRTOP, which simultaneously optimises the routes as well … Read more
We derive a closed form description of the convex hull of mixed-integer bilinear covering set with bounds on the integer variables. This convex hull description is determined by considering some orthogonal disjunctive sets defined in a certain way. This description does not introduce any new variables, but consists of exponentially many inequalities. An extended formulation … Read more
Many mixed-integer optimization problems are constrained by nonlinear functions that do not possess desirable analytical properties like convexity or factorability or cannot even be evaluated exactly. This is, e.g., the case for problems constrained by differential equations or for models that rely on black-box simulation runs. For these problem classes, we present, analyze, and test … Read more
The minimum $k$-enclosing ball problem seeks the ball with smallest radius that contains at least $k$ of $m$ given points in a general $n$-dimensional Euclidean space. This problem is NP-hard. We present a branch-and-bound algorithm on the tree of the subsets of $k$ points to solve this problem. The nodes on the tree are ordered … Read more
Process systems engineers have long recognized the importance of both logic and optimization for automated decision-making. But modern challenges in process systems engineering could strongly benefit from methodological contributions in computer science. In particular, we propose satisfiability modulo theories (SMT) for process systems engineering applications. We motivate SMT using a series of test beds and … Read more
Motivated by recent advances in solution methods for mixed-integer convex optimization (MICP), we study the fundamental and open question of which sets can be represented exactly as feasible regions of MICP problems. We establish several results in this direction, including the first complete characterization for the mixed-binary case and a simple necessary condition for the … Read more
We propose a method for solving mixed-integer nonlinear programs (MINLPs) to global optimality by discretization of occuring nonlinearities. The main idea is based on using piecewise linear functions to construct mixed-integer linear program (MIP) relaxations of the underlying MINLP. In order to find a global optimum of the given MINLP we develope an iterative algorithm … Read more