This paper presents a novel application of operations research techniques to the analysis of HIV env gene sequences, aiming to identify key features that are possible vaccine targets. These targets are identified as being critical to the transmission of HIV by being present in early transmitted (founder) sequences and absent in later chronic sequences. Identifying … Read more
In this paper, we propose a novel, unified, general approach to investigate sufficient and necessary conditions under which four types of convex sets, polyhedra, polyhedral cones, ellipsoids and Lorenz cones, are invariant sets for a linear continuous or discrete dynamical system. In proving invariance of ellipsoids and Lorenz cones for discrete systems, instead of the … Read more
In this paper we are interested in the solution of Compressed Sensing (CS) problems where the signals to be recovered are sparse in coherent and redundant dictionaries. CS problems of this type are convex with non-smooth and non-separable regularization term, therefore a specialized solver is required. We propose a primal-dual Newton Conjugate Gradients (pdNCG) method. … Read more
We consider a problem in eigenvalue optimization, in particular find- ing a local minimizer of the spectral abscissa – the value of a parameter that results in the smallest magnitude of the largest real part of the spectrum of a matrix system. This is an important problem for the stabilization of control sys- tems. Many … Read more
We consider power networks in which it is not possible to satisfy all loads at the demand nodes, due to some attack or disturbance to the network. We formulate a model, based on AC power flow equations, to restore the network to feasibility by shedding load at demand nodes, but doing so in a way … Read more
The goal of this paper is to identify the most promising sets of closest assignment constraints from the literature, in order to improve mixed integer linear programming formulations for exploration of information flow within a social network. The direct comparison between proposed formulations is performed on standard single source capacitated facility location problem instances. Therefore, … Read more
A lot of real-world optimization models comprise nonconvex and nonlinear as well as nonsmooth functions leading to very hard classes of optimization models. In this article a new interior-point method for the special but practically relevant class of optimization problems with locatable and separable nonsmooth aspects is presented. After motivating and formalizing the problems under … Read more
This paper presents a linear programming approach for the optimal control of nonlinear switched systems where the control is the switching sequence. This is done by introducing modal occupation measures, which allow to relax the problem as a primal linear programming (LP) problem. Its dual linear program of Hamilton-Jacobi-Bellman inequalities is also characterized. The LPs … Read more
This paper shows how, in a quasi metric space, an inexact proximal algorithm with a generalized perturbation term appears to be a nice tool for Behavioral Sciences (Psychology, Economics, Management, Game theory,…). More precisely, the new perturbation term represents an index of resistance to change, defined as a “curved enough” function of the quasi distance … Read more
In this article we survey mathematical programming approaches to problems in the field of water network optimization. Predominant in the literature are two different, but related problem classes. One can be described by the notion of network design, while the other is more aptly termed by network operation. The basic underlying model in both cases … Read more