Optimizing Diesel Fuel Supply Chain Operations for Hurricane Relief

Hurricanes can cause severe property damage and casualties in coastal regions. Diesel fuel plays a crucial role in hurricane disaster relief. It is important to optimize fuel supply chain operations so that emergency demand for diesel can be mitigated in a timely manner. However, it can be challenging to estimate demand for fuel and make … Read more

Aid Allocation for Camp-Based and Urban Refugees with Uncertain Demand and Replenishments

There are nearly 26 million refugees worldwide seeking safety from persecution, violence, conflict, and human rights violations. Camp-based refugees are those that seek shelter in refugee camps, whereas urban refugees inhabit nearby, surrounding populations. The systems that supply aid to refugee camps may suffer from ineffective distribution due to challenges in administration, demand uncertainty and … Read more

Optimising the assignment of swabs and reagents for PCR testing during a viral epidemic

Early large-scale swab testing is a fundamental tool for health authorities to assess the prevalence of a virus and enact appropriate mitigation measures during an epidemic. The COVID-19 pandemic has shown that the availability of chemical reagents required to carry out the tests is often a bottleneck in increasing a country’s testing capacity. Further, demand … Read more

Interdependence and Integration among Components of the Airline Scheduling Process: A State-of-the-Art Review

Over the last few decades, the Airline Scheduling Process (ASP) has received an unprecedented attention from airliners and operations research society. Conventionally, the Airline Scheduling Process is decomposed into four sub-problems namely-Schedule Generation, Fleet Assignment, aircraft Routing, and Crew Scheduling which are solved sequentially in order to incorporate tractability and feasibility in the overall process. … Read more

One transfer per patient suffices: Structural insights about patient-to-room assignment

While many heuristics have been proposed for the problem of patient-to-room assignment (PRA) with a large variety of different practical constraints, a thorough investigation of the problem’s structure itself has been neglected so far. Therefore, in this paper, we present insights about the basic, underlying combinatorial problem of PRA. At first we consider the problem … Read more

Data Approximation by L1 Spline Fits with Free Knots

L1 spline fits are a class of spline models that have shown advantages in approximating irregular and multiscale data. This paper investigates the knot placement problem of L1 spline fits under two scenarios. If the number of knots is given, we propose an augmented Lagrangian method to solve the bilevel L1 spline fit problem and … Read more

Portfolio-wide Optimization of Pharmaceutical R&D Activities Using Mathematical Programming

The R&D management in any major research pharmaceutical company is constantly faced with the need to make complicated activity scheduling and resource allocation decisions, as they carry out scientific work to develop new therapeutic products. This paper describes how we develop a decision support tool that allows practitioners to determine portfolio-wide optimal schedules in a … Read more

A Distributionally Robust Optimization Approach for Stochastic Elective Surgery Scheduling with Limited Intensive Care Unit Capacity

In this paper, we study the decision process of assigning elective surgery patients to available surgical blocks in multiple operating rooms (OR) under random surgery durations, random postoperative length-of-stay in the intensive care unit (ICU), and limited capacity of ICU. The probability distributions of random parameters are assumed to be ambiguous, and only the mean … Read more

The Multi-Stop Station Location Problem

We introduce the (directed) multi-stop station location problem. The goal is to install stations such that ordered (multi-)sets of stops can be traversed with respect to range restrictions that are reset whenever a station is visited. Applications arise in telecommunications and transportation, e.g., charging station placement problems. The problem generalizes several network optimization problems such … Read more

A New Coherent Multivariate Average-Value-at-Risk

A new multivariate performance measure Average-Value-at-Risk, mAVaR αevaluating the sum of N risky assets composing the portfolio of an investor with respect to riskN-dimensional risk level vectorαis proposed. We show that the proposed operator satisfies the four axioms of a coherent risk measure, while reducing to the one variableAverage-Value-at-RiskAVaR, in caseN= 1. In that respect, … Read more