This paper addresses the manufacturing and distribution of short-lived radio-pharmaceuticals which are mainly used in diagnostic imaging studies. We develop a mixed integer nonlinear optimization model that is flexible enough to capture the complex underlying nuclear physics of the production process of fludeoxyglucose (FDG), which is widely used in oncology and cardiology, as well as … Read more
We introduce a new generalization of the classical planar maximum coverage location problem (PMCLP) in which demand zones and service zone of each facility are represented by spatial objects such as circles, polygons, etc., and are allowed to be located anywhere in a continuous plane. In addition, we allow partial coverage in its true sense, … Read more
This paper presents the development of an enhanced L-Shaped method applied to an inventory management problem that considers a replenishment control system based on the periodic review (R,S) policy. We consider single-item one-echelon problems with uncertain demands and partial backorder that are modeled using two-stage stochastic programming. To enable the consideration of large-scale problems, the … Read more
In this paper, we consider the well-known constant-batch lot-sizing problem, which we refer to as the single module capacitated lot-sizing (SMLS) problem, and multi-module capacitated lot-sizing (MMLS) problem. We provide sufficient conditions under which the (k,l,S,I) inequalities of Pochet and Wolsey (Math of OR 18: 767-785, 1993), the mixed (k,l,S,I) inequalities, derived using mixing procedure … Read more
This paper studies the vehicle routing problem with time windows and multiple deliverymen in which customer demands are uncertain and belong to a predetermined polytope. In addition to the routing decisions, this problem aims to define the number of deliverymen used to provide the service to the customers on each route. A new mathematical formulation … Read more
This paper examines the impacts of governmental incentives for coal-fired power plants to generate renewable energy via biomass cofiring technology. The most common incentive is the production tax credit (PTC), a flat rate reimbursement for each unit of renewable energy generated. The work presented here proposes PTC alternatives, incentives that are functions of plant capacity … Read more
We study a multiechelon supply chain model that consists of a production level and several transportation levels, where the demands can exist in the production echelon as well as any transportation echelons. With the presence of stationary production capacity and general cost functions, our model integrates production, inventory and transportation decisions and generalizes existing literature … Read more
We study robust versions of the uncapacitated lot sizing problem, where the demand is subject to uncertainty. The robust models are guided by three parameters, namely, the total scaled uncertainty budget, the minimum number of periods in which one would like the demand to be protected against uncertainty, and the minimum scaled protection level per … Read more
We present a two-stage stochastic linear programming model to manage the inventory of vaccine vials in developing countries. In these countries immunization programs often involve targeted outreach services in remote locations. Organizations managing these programs are in need of tools which identify inventory replenishment and vaccine utilization plans to minimize costs and wastage while achieving … Read more
We study the one-warehouse multi-retailer (OWMR) problem under deterministic dynamic demand and concave batch order costs, where order batches have an identical capacity and the order cost function for each facility is concave within the batch. Under appropriate assumptions on holding cost structure, we obtain lower bounds via a decomposition that splits the two-echelon problem … Read more