We study the numerical solution of the problem $\min_{X \ge 0} \|BX-c\|2$, where $X$ is a symmetric square matrix, and $B$ a linear operator, such that $B^*B$ is invertible. With $\rho$ the desired fractional duality gap, we prove $O(\sqrt{m}\log\rho^{-1})$ iteration complexity for a simple primal-dual interior point method directly based on those for linear programs … Read more
In this paper, we propose and study a unified mixed-integer programming model that simultaneously optimizes fluence weights and multi-leaf collimator (MLC) apertures in the treatment planning optimization of VMAT, Tomotherapy, and CyberKnife. The contribution of our model is threefold: i. Our model optimizes the fluence and MLC apertures simultaneously for a given set of control … Read more
Purpose: To describe and mathematically validate the superiorization methodology, which is a recently-developed heuristic approach to optimization, and to discuss its applicability to medical physics problem formulations that specify the desired solution (of physically given or otherwise obtained constraints) by an optimization criterion. Methods: The superiorization methodology is presented as a heuristic solver for a … Read more
We consider the convex feasibility problem (CFP) in Hilbert space and concentrate on the study of string-averaging projection (SAP) methods for the CFP, analyzing their convergence and their perturbation resilience. In the past, SAP methods were formulated with a single predetermined set of strings and a single predetermined set of weights. Here we extend the … Read more
The problem of packing ellipsoids of different sizes and shapes into an ellipsoidal container so as to minimize a measure of overlap between ellipsoids is considered. A bilevel optimization formulation is given, together with an algorithm for the general case and a simpler algorithm for the special case in which all ellipsoids are in fact … Read more
We propose a novel, ecient approach for obtaining high-quality experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). Our approach combines a greedy hillclimbing algorithm and a cyclic permutation method. When searching for optimal ER-fMRI designs, the proposed approach focuses only on a promising restricted class of designs with equal frequency of occurrence across stimulus … Read more
In this paper we consider robust models of surge capacity plans to be deployed in the event of a flu pandemic. In particular, we focus on managing critical staff levels at organizations that must remain operational during such an event. We develop efficient procedures for managing emergency resources so as to minimize the impact of … Read more
This paper presents a new two-phase solution approach to the beam angle and fluence map optimization problem in Intensity Modulated Radiation Therapy (IMRT) planning. We introduce Branch-and-Prune (B&P) to generate a robust feasible solution in the first phase. A local neighborhood search algorithm is developed to find a local optimal solution from the Phase I … Read more
We consider the problem of approximating the Pareto set of convex multi-criteria optimization problems by a discrete set of points and their convex combinations. Finding the scalarization parameters that maximize the improvement in bound on the approximation error when generating a single Pareto optimal solution is a nonconvex optimization problem. This problem is solvable by … Read more
The Distance Geometry Problem in three dimensions consists in finding an embedding in R^3 of a given nonnegatively weighted simple undirected graph such that edge weights are equal to the corresponding Euclidean distances in the embedding. This is a continuous search problem that can be discretized under some assumptions on the minimum degree of the … Read more