Parsimonious haplotype estimation from aligned Single Nucleotide Polymorphism (SNP) fragments consists of finding the minimum number of haplotypes necessary to explain a given set of genotypes. This problem is known to be NP-Hard. Here we describe a new integer linear-programming model to tackle this problem based on the concept of class representatives, already used for … Read more
We consider the problem of clustering a set of items into subsets whose sizes are bounded from above and below. We formulate the problem as a graph partitioning problem and propose an integer programming model for solving it. This formulation generalizes several well-known graph partitioning problems from the literature like the clique partitioning problem, the … Read more
We consider the problem of clustering a set of items into subsets whose sizes are bounded from above and below. We formulate the problem as a graph partitioning problem and propose an integer programming model for solving it. This formulation generalizes several well-known graph partitioning problems from the literature like the clique partitioning problem, the … Read more
Orbital branching is a method for branching on variables in integer programming that reduces the likelihood of evaluating redundant, isomorphic nodes in the branch-and-bound procedure. In this work, the orbital branching methodology is extended so that the branching disjunction can be based on an arbitrary constraint. Many important families of integer programs are structured such … Read more
We analyze two integer programming reformulations of the n-dimensional knapsack feasibility problem without assuming any structure on the weight vector $a.$ Both reformulations have a constraint matrix in which the columns form a reduced basis in the sense of Lenstra, Lenstra, and Lov\’asz. The nullspace reformulation of Aardal, Hurkens and Lenstra has n-1 variables, and … Read more
In financial markets high levels of risk are associated with large returns as well as large losses, whereas with lower levels of risk, the potential for either return or loss is small. Therefore, risk management is fundamentally concerned with finding an optimal trade-off between risk and return matching an investor’s risk tolerance. Managing risk is … Read more
Mixed-integer rounding (MIR) is a simple, yet powerful procedure for generating valid inequalities for mixed-integer programs. When used as cutting planes, MIR inequalities are very effective for problems with unbounded integer variables. For problems with bounded integer variables, however, cutting planes based on lifting techniques appear to be more effective. This is not surprising as … Read more
Lifting is a procedure for deriving valid inequalities for mixed-integer sets from valid inequalities for suitable restrictions of those sets. Lifting has been shown to be very effective in developing strong valid inequalities for linear integer programming and it has been successfully used to solve such problems with branch-and-cut algorithms. Here we generalize the theory … Read more
The aim of this paper is to provide new efficient methods for solving general chance-constrained integer linear programs to optimality. Valid linear inequalities are given for these problems. They are proved to characterize properly the set of solutions. They are based on a specific scenario, whose definition impacts strongly on the quality of the linear … Read more
We consider optimization problems with some binary variables, where the objective function is linear in these variables. The stability region of a given solution of such a problem is the polyhedral set of objective coefficients for which the solution is optimal. A priori knowledge of this set provides valuable information for sensitivity analysis and re-optimization … Read more