Adverse drug reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reactions that they cause. We formulate the drug-reaction relationship problem as a continuous optimization problem and … Read more
We consider the computational complexity of optimizing various classes of continuous functions over a simplex, hypercube or sphere. These relatively simple optimization problems have many applications. We review known approximation results as well as negative (inapproximability) results from the recent literature. Citation CentER Discussion paper 2006-85 Tilburg University THe Netherlands Article Download View The complexity … Read more
Continuous GRASP (C-GRASP) is a stochastic local search metaheuristic for finding cost-efficient solutions to continuous global optimization problems subject to box constraints (Hirsch et al., 2006). Like a greedy randomized adaptive search procedure (GRASP), a C-GRASP is a multi-start procedure where a starting solution for local improvement is constructed in a greedy randomized fashion. In … Read more
In this paper we consider global optimization algorithms based on multiple local searches for the Molecular Distance Geometry Problem (MDGP). Three distinct approaches (Multistart, Monotonic Basin Hopping, Population Basin Hopping) are presented and for each of them a computational analysis is performed. The results are also compared with those of two other approaches in the … Read more
In this paper we study various approaches for exploiting symmetries in polynomial optimization problems within the framework of semi definite programming relaxations. Our special focus is on constrained problems especially when the symmetric group is acting on the variables. In particular, we investigate the concept of block decomposition within the framework of constrained polynomial optimization … Read more
In this paper we show that for discrete concave functions, a local maximum need not be a global maximum. We also provide examples of discrete concave functions where this coincidence holds. As a direct consequence of this, we can establish the equivalence of local and global profit maximizers for an equivalent well-behaved production function that … Read more
The Lipschitz Global Optimizer (LGO) software integrates global and local scope search methods, to handle nonlinear optimization models. Here we discuss the LGO implementation linked to the General Algebraic Modeling System (GAMS). First we review the key features and basic usage of the GAMS /LGO solver option, then present reproducible numerical results to illustrate its … Read more
We consider the problem of minimizing a univariate, real-valued function f on an interval [a,b]. When f is a polynomial, we review how this problem may be reformulated as a semidefinite programming (SDP) problem, and review how to extract all global minimizers from the solution of the SDP problem. For general f, we approximate the … Read more
We describe improvements to Smith’s branch-and-bound (B&B) algorithm for the Euclidean Steiner problem in R^d. Nodes in the B&B tree correspond to full Steiner topologies associated with a subset of the terminal nodes, and branching is accomplished by “merging” a new terminal node with each edge in the current Steiner tree. For a given topology … Read more
We consider a polynomial programming problem P on a compact basic semi-algebraic set K described by m polynomial inequalities $g_j(X)\geq0$, and with polynomial criterion $f$. We propose a hierarchy of semidefinite relaxations in the spirit those of Waki et al. [9]. In particular, the SDP-relaxation of order $r$ has the following two features: (a) The … Read more