The LASSO-Patternsearch algorithm is proposed as a two-step method to identify clusters or patterns of multiple risk factors for outcomes of interest in demographic and genomic studies. The predictor variables are dichotomous or can be coded as dichotomous. Many diseases are suspected of having multiple interacting risk factors acting in concert, and it is of … Read more
Orbital branching is a method for branching on variables in integer programming that reduces the likelihood of evaluating redundant, isomorphic nodes in the branch-and-bound procedure. In this work, the orbital branching methodology is extended so that the branching disjunction can be based on an arbitrary constraint. Many important families of integer programs are structured such … Read more
New images of a three-dimensional scene can be generated from known image sequences using lightfields. To get high quality images, it is important to have accurate information about the structure of the scene. In order to optimize this information, we define a residual-function. This function represents the difference between an image, rendered in a known … Read more
Very hard optimization problems, i.e., problems with a large number of variables and local minima, have been effectively attacked with algorithms which mix local searches with heuristic procedures in order to widely explore the search space. A Population Based Approach based on a Monotonic Basin Hopping optimization algorithm has turned out to be very effective … Read more
New approximate secant equations are shown to result from the knowledge of (problem dependent) invariant subspace information, which in turn suggests improvements in quasi-Newton methods for unconstrained minimization. It is also shown that this type of information may often be extracted from the multigrid structure of discretized infinite dimensional problems. A new limited-memory BFGS using … Read more
Radiation therapy is an important modality in treating various cancers. Various treatment planning and delivery technologies have emerged to support Intensity Modulated Radiation Therapy (IMRT), creating significant opportunities to advance this type of treatment. We investigate the possibility of including the dose prescription, specified by the DVH, within the convex optimization framework for inverse IMRT … Read more
Intensity–modulated radiation therapy (IMRT) gives rise to systems of linear inequalities, representing the effects of radiation on the irradiated body. These systems are often infeasible, in which case one settles for an approximate solution, such as an {a,ß}–relaxation, meaning that no more than a percent of the inequalities are violated by no more than ß … Read more
In this work, a regression problem is studied where the elements of the database are sets with certain geometrical properties. In particular, our model can be applied to handle data affected by some kind of noise or uncertainty and interval-valued data, and databases with missing values as well. The proposed formulation is based on the … Read more
We study a system of linear inequalities associated with the uncapacitated facility location problem. We show that this system defines a polytope with integer extreme points if and only if the graph does not contain a certain type of odd cycles. We also derive odd cycle inequalities and give a separation algorithm. ArticleDownload View PDF
A support vector machine (SVM) determines whether a given observed pattern lies in a particular class. The decision is based on prior training of the SVM on a set of patterns with known classification, and training is achieved by solving a convex quadratic programming problem. Since there are typically a large number of training patterns, … Read more