We are interested in optimizing the co-administration of two drugs for some acute myeloid leukemias (AML), and we are looking for in vitro protocols as a first step. This issue can be formulated as an optimal control problem. The dynamics of leukemic cell populations in culture is given by age-structured partial differential equations, which can … Read more
We consider polynomial differential equations and make a number of contributions to the questions of (i) complexity of deciding stability, (ii) existence of polynomial Lyapunov functions, and (iii) existence of sum of squares (sos) Lyapunov functions. (i) We show that deciding local or global asymptotic stability of cubic vector fields is strongly NP-hard. Simple variations … Read more
Despite the importance of a thermodynamically stable structure with a conserved fold for protein function, almost all evolutionary models neglect site-site correlations that arise from physical interactions between neighboring amino acid sites. This is mainly due to the difficulty in formulating a computationally tractable model since rate matrices can no longer be used. Here we … Read more
Directional sensors are gaining importance due to applications, in- cluding surveillance, detection, and tracking. Such sensors have a limited fi eld-of-view and a discrete set of directions they can be pointed to. The Directional Sensor Control problem (DSCP) consists in assigning a direction of view to each sensor. The location of the targets is known with … Read more
We propose a distributed positioning algorithm to estimate the unknown positions of a number of target nodes, given distance measurements between target nodes and between target nodes and a number of reference nodes at known positions. Based on a geometric interpretation, we formulate the positioning problem as an implicit convex feasibility problem in which some … Read more
The projected subgradient method for constrained minimization repeatedly interlaces subgradient steps for the objective function with projections onto the feasible region, which is the intersection of closed and convex constraints sets, to regain feasibility. The latter poses a computational difficulty and, therefore, the projected subgradient method is applicable only when the feasible region is “simple … Read more
We propose a variable metric framework for minimizing the sum of a self-concordant function and a possibly non-smooth convex function endowed with a computable proximal operator. We theoretically establish the convergence of our framework without relying on the usual Lipschitz gradient assumption on the smooth part. An important highlight of our work is a new … Read more
We present new models, numerical simulations and rigorous analysis for the optimization of the velocity in a race. In a seminal paper, Keller (1973,1974) explained how a runner should determine his speed in order to run a given distance in the shortest time. We extend this analysis, based on the equation of motion and aerobic … Read more
We present a number of results on inverse parametric optimization and its application to hybrid system control. We show that any function that can be written as the difference of two convex functions can also be written as a linear mapping of the solution to a convex parametric optimization problem. We exploit these results in … Read more
Controlled tabular adjustment (CTA) is an emerging protection technique for tabular data protection. CTA formulates a mixed integer linear programming problem, which is tough for tables of moderate size. Finding a feasible initial solution may even be a challenging task for large instances. On the other hand, end users of tabular data protection techniques give … Read more