Accelerated proximal gradient methods have become a useful tool in large-scale convex optimization, specially for variational regularization with non-smooth priors. Prevailing convergence analysis considers that users can perform the proximal and the gradient steps exactly. Still, in some practical applications, the proximal or the gradient steps must be computed inexactly, which can harm convergence speed … Read more
In this paper we propose an approach for solving systems of nonlinear equations without computing function derivatives. Motivated by the application area of tomographic absorption spectroscopy, which is a highly-nonlinear problem with variables coupling, we consider a situation where straightforward translation to a fixed point problem is not possible because the operators that represent the … Read more
In proton therapy treatment planning, the aim is to ensure tumor control while sparing the various surrounding risk structures. The biological effect of the irradiation depends on both physical dose and linear energy transfer (LET). In order to include LET alongside physical dose in plan creation, we propose to formulate the proton treatment planning problem … Read more
We propose a new multi-model partially observable Markov decision process (MPOMDP) model to address the issue of model ambiguity in partially observable Markov decision process. Here, model ambiguity is defined as the case where there are multiple credible optimization models with the same structure but different model parameters. The proposed MPOMDP model aims to learn … Read more
The superiorization methodology can be thought of as lying conceptually between feasibility-seeking and constrained minimization. It is not trying to solve the full-fledged constrained minimization problem composed from the modeling constraints and the chosen objective function. Rather, the task is to find a feasible point which is “superior” (in a well-defined manner) with respect to … Read more
Objective: We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a feasibility-seeking projection algorithm will seek a feasible point. This algorithm is then perturbed with gradient descent steps to reduce a nonlinear objective function. Approach: Within … Read more
In this paper we study the split minimization problem that consists of two constrained minimization problems in two separate spaces that are connected via a linear operator that maps one space into the other. To handle the data of such a problem we develop a superiorization approach that can reach a feasible point with reduced … Read more
We summarize recent results and ongoing activities in mathematical algorithms and computer science methods related to proton computed tomography (pCT) and intensitymodulated particle therapy (IMPT) treatment planning. Proton therapy necessitates a high level of delivery accuracy to exploit the selective targeting imparted by the Bragg peak. For this purpose, pCT utilizes the proton beam itself … Read more
The COVID-19 pandemic has had an unprecedented impact on global health and the economy since its inception in December, 2019 in Wuhan, China. Non-pharmaceutical interventions (NPI) like lockdowns and curfews have been deployed by affected countries for controlling the spread of infections. In this paper, we develop a Mixed Integer Non-Linear Programming (MINLP) epidemic model … Read more
The COVID-19 pandemic has had an unprecedented impact on global health and the economy since its inception in December, 2019 in Wuhan, China. Non-pharmaceutical interventions (NPI) like lockdowns and curfews have been deployed by affected countries for controlling the spread of infections. In this paper, we develop a Mixed Integer Non-Linear Programming (MINLP) epidemic model … Read more