Multimodal chromatography is a powerful tool in the downstream processing of biopharmaceuticals. To fully benefit from this technology, an efficient process strategy must be determined beforehand. To facilitate this task, we employ a recent mechanistic model for multimodal chromatography, which takes salt concentration and pH into account, and we present a mathematical framework for the … Read more
In 2020, DIDO© turned 20! The software package emerged in 2001 as a basic, user-friendly MATLAB teaching tool to illustrate the various nuances of Pontryagin’s Principle but quickly rose to prominence in 2007 after NASA announced it had executed a globally optimal maneuver using DIDO. Since then, the toolbox has grown in applications well beyond … Read more
We investigate an extension of Mixed-Integer Optimal Control Problems (MIOCPs) by adding switching costs, which enables the penalization of chattering and extends current modeling capabilities. The decomposition approach, consisting of solving a partial outer convexification to obtain a relaxed solution and using rounding schemes to obtain a discrete-valued control can still be applied, but the … Read more
In the context of multistage stochastic optimization, it is natural to consider nested risk measures, which originate by repeatedly composing risk measures, conditioned on realized observations. Starting from this discrete time setting, we extend the notion of nested risk measures to continuous time by adapting the risk levels in a time dependent manner. This time … Read more
In this work, nonconvex nonsmooth problems of dynamic optimization, optimal control in discrete time (including feedback control), and machine learning are considered from a common point of view. An analogy is observed between tasks of controlling discrete dynamic systems and training multilayer neural networks with nonsmooth target function and connections. Methods for calculating generalized gradients … Read more
Tailored mixed-integer optimal control policies for real-world applications usually have to avoid very short successive changes of the active integer control. Minimum dwell time constraints express this requirement and can be included into the combinatorial integral approximation decomposition, which solves mixed-integer optimal control problems by solving one continuous nonlinear program and one mixed-integer linear program. … Read more
Optimal control problems including partial differential equation (PDE) as well as integer constraints merge the combinatorial difficulties of integer programming and the challenges related to large-scale systems resulting from discretized PDEs. So far, the Branch-and-Bound framework has been the most common solution strategy for such problems. In order to provide an alternative solution approach, especially … Read more
This paper is devoted to optimal control of dynamical systems governed by differential inclusions in both frameworks of Lipschitz continuous and discontinuous velocity mappings. The latter framework mostly concerns a new class of optimal control problems described by various versions of the so-called sweeping/Moreau processes that are very challenging mathematically and highly important in applications … Read more
Within this work, we present a warm-started algorithm for Model Predictive Control (MPC) of switched nonlinear systems under combinatorial constraints based on Combinatorial Integral Approximation (CIA). To facilitate high-speed solutions, we introduce a preprocessing step for complexity reduction of CIA problems, and include this approach within a new toolbox for solution of CIA problems with … Read more
We study the following optimization problem over a dynamical system that consists of several linear subsystems: Given a finite set of n-by-n matrices and an n-dimensional vector, find a sequence of K matrices, each chosen from the given set of matrices, to maximize a convex function over the product of the K matrices and the … Read more