The purpose of this study is to give an exact formulation of optimization of volumetric-modulated arc therapy (VMAT) with sliding-window delivery, and to investigate the plan quality effects of decreasing the number of sliding-window sweeps made on the 360-degree arc for a faster VMAT treatment. In light of the exact formulation, we interpret an algorithm … Read more
The main focus in this paper is exact linesearch methods for minimizing a quadratic function whose Hessian is positive definite. We give two classes of limited-memory quasi-Newton Hessian approximations that generate search directions parallel to those of the method of preconditioned conjugate gradients, and hence give finite termination on quadratic optimization problems. The Hessian approximations … Read more
The most effective software packages for solving mixed 0-1 linear programs use strong valid linear inequalities derived from polyhedral theory. We introduce a new procedure which enables one to take known valid inequalities for the knapsack polytope, and convert them into valid inequalities for the fixed-charge and single-node flow polytopes. The resulting inequalities are very … Read more
We understand linear convergence of some first-order methods such as the proximal gradient method (PGM), the proximal alternating linearized minimization (PALM) algorithm and the randomized block coordinate proximal gradient method (R-BCPGM) for minimizing the sum of a smooth convex function and a nonsmooth convex function from a variational analysis perspective. We introduce a new analytic … Read more
Despite the rich literature, the linear convergence of alternating direction method of multipliers (ADMM) has not been fully understood even for the convex case. For example, the linear convergence of ADMM can be empirically observed in a wide range of applications, while existing theoretical results seem to be too stringent to be satisfied or too … Read more
Deep learning has recently attracted a significant amount of attention due to its great empirical success. However, the effectiveness in training deep neural networks (DNNs) remains a mystery in the associated nonconvex optimizations. In this paper, we aim to provide some theoretical understanding on such optimization problems. In particular, the Kurdyka-{\L}ojasiewicz (KL) property is established … Read more
We present the PyMOSO software package for (1) solving multi-objective simulation optimization (MOSO) problems on integer lattices, and (2) implementing and testing new simulation optimization (SO) algorithms. First, for solving MOSO problems on integer lattices, PyMOSO implements R-PERLE, a state-of-the-art algorithm for two objectives, and R-MinRLE, a competitive benchmark algorithm for three or more objectives. … Read more
We study the class of nonsmooth nonconvex problems in which the objective is to minimize the difference between a continuously differentiable function (possibly nonconvex) and a convex (possibly nonsmooth) function over a convex polytope. This general class contains many types of problems, including difference of convex functions (DC) problems, and as such, can be used … Read more
Principal component analysis (PCA) is one of the most widely used dimensionality reduction tools in scientific data analysis. The PCA direction, given by the leading eigenvector of a covariance matrix, is a linear combination of all features with nonzero loadings—this impedes interpretability. Sparse principal component analysis (SPCA) is a framework that enhances interpretability by incorporating … Read more
Gradient-based optimization algorithms can be studied from the perspective of limiting or- dinary differential equations (ODEs). Motivated by the fact that existing ODEs do not distin- guish between two fundamentally different algorithms—Nesterov’s accelerated gradient method for strongly convex functions (NAG-SC) and Polyak’s heavy-ball method—we study an alter- native limiting process that yields high-resolution ODEs. We … Read more